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Abstract #0687

The First MRI Detection of Prion Protein Plaques in the Cerebral Cortex in Variant Creutzfeldt-Jakob Disease: Post Mortem MR Microscopy at 9.4 Tesla

Harpreet Hyare1, Po-Wah So2, Caroline Powell1, Thornton John3, Tarek Yousry3, Sebastian Brandner1, Harry Parkes4

1MRC Prion Unit, UCL Institute of Neurology, London, United Kingdom; 2Institute of Psychiatry, London, United Kingdom; 3National Hospital for Neurology and Neurosurgery; 4Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, London, United Kingdom

Magnetic resonance microscopy at 9.4T with in plane resolution of 58 microns can depict amyloid plaques composed of the abnormal prion protein in the cortex of patients with vCJD. Formalin fixed cortical samples, passively stained with gadoteric acid and scanned with a high resolution 3D gradient echo sequence (TR 20, TE 5, 16 averages) demonstrate prion protein (PrP) plaques as hypointense foci in the cortex which correspond to PrP immunostaining. As high field strength magnets enter clinical practice, in vivo MRI of the cortex may improve diagnosis and monitoring of vCJD.