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Abstract #0692

Assessment of Motion and F0 Artifacts in 7T High Resolution T2*-Weighted Imaging in Alzheimers Disease Patients, and Application of a Navigator-Based Correction Scheme

Maarten J. Versluis1,2, Johannes M. Peeters3, Sanneke van Rooden1,2, Jeroen van der Grond1, Mark A. van Buchem1, Andrew G. Webb1,2, Matthias J. van Osch1,2

1Radiology, Leiden University Medical Center, Leiden, Netherlands; 2CJ Gorter Center for High Field MRI, Leiden University Medical Center, Leiden, Netherlands; 3Philips Healthcare, Best, Netherlands

Image quality is decreased substantially in 7T high resolution T2*-weighted images in Alzheimers disease (AD) patients compared to younger volunteers. The source of the image artifacts was investigated in phantom experiments using translational/rotational motion parameters and f0 fluctuations from AD patients. It was found that image degradation by f0 fluctuations was a factor-of-four times larger than artifacts caused by movement typical of AD patients. By implementing a navigator echo correction for f0 fluctuations, the image quality increased considerably. This technique was succesfully applied in four AD patients showing significant image quality improvements.