Yufen Chen1, Hong I. Wan2, John P. O'Reardon3, Marc Korczykowski1, Ze wang1, Jiongjiong Wang1, John A. Detre1
1Center of Functional Neuroimaging, University of Pennsylvania, Philadelphia, PA, United States; 2Clinical Translational Medicine, Pfizer Inc, Collegeville , PA, United States; 3Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, United States
Arterial spin labeling (ASL) is a favorable alternative to blood-oxygenation-level-dependent (BOLD)based pharmacological MRI (phMRI) as it offers an easily interpreted, quantitative measurement of cerebral blood flow (CBF). We investigate the feasibility of ASL phMRI to detect the effects of a single orally administered dose of citaloprama commonly used antidepressantin healthy subjects. Our results reveal a significant drug-induced reduction in CBF within the amygdala. This result is in agreement with prior studies that show a correlation between amygdala function and depression, and indicates that ASL phMRI is a valuable tool for clinical trials.