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Abstract #0725

3D Regional Measurements of Alveolar Surface Area Using 90 Single Breath XTC

Samuel Patz1, Iga Muradyan1, Mikayel Dabaghyan1, Isabel Maria Dregely2, Mirko I. Hrovat3, Hiroto Hatabu1, F William Hersman4, Iulian C. Ruset4, James P. Butler5

1Department of Radiology, Brigham and Women's Hospital, Boston, MA, United States; 2Department of Physics, University of New Hampshire, Durham, NH, United States; 3Mirtech, Inc, Brockton, MA, United States; 4Xemed, LLC, Durham, NH, United States; 5Department of Environmental Health, Harvard School of Public Health, Boston, MA, United States

Alveolar surface area is a key determinant of the severity of emphysema. Hence it is important to obtain regional maps of this parameter in order to evaluate disease heterogeneity. To accomplish this goal, we obtained 3D regional measurements of alveolar surface area per unit volume by measuring the septal uptake of hyperpolarized 129Xe. Single Breath XTC was used but 90 RF pulses were used for the selective tissue phase pulses rather than the traditional 180 pulses.