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Abstract #0727

Separation of Sodium Compartments for Characterization of Tumor Tissue by 23Na-MRI

Armin Michael Nagel1, Michael Bock1, Christian Matthies1, Marc-Andr Weber2, Stephanie Combs3, Wolfhard Semmler1, Armin Biller, 2

1Medical Physics in Radiology, German Cancer Research Center, Heidelberg, Germany; 2Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, Germany; 3Department of Radiation Oncology, University Hospital Heidelberg, Germany

In this work brain-tumor patients were investigated with different 23Na-image contrasts (spin-density, 23Na-FLAIR) to gain information from which compartment the 23Na-signal originates. Using a 23Na-FLAIR sequence different 23Na-compartments in many brain tumors can be suppressed, whereas other parts still exhibit a high 23Na-FLAIR-signal. Our findings indicate that a combination of both 23Na-sequences allows for separating different 23Na compartments. Distinguishing these compartments might be important for the determination of potential tumor malignancy.