Meeting Banner
Abstract #0731

Phase Contrast Based MR Microscopy of Glial Tumor Cells Using Microcoils

Nicoleta Baxan1, Ulf Kahlert2, Hans Weber1, Mohammad Mohammadzadeh1, Juergen Hennig1, Dominik von Elverfeldt1

1Diagnostic Radiology, Medical Physics, University Hospital, Freiburg, Germany; 2Stereotactic Neurosurgery, University Hospital , Freiburg, Germany

The contrast mechanism employed for differentiating structures in micron-scale samples is of great interest especially when is combined with high-resolution MRI and an adequate SNR. In this study, phase contrast together with the susceptibility weighted imaging (SWI) technique was performed for imaging living glial tumor cells. Our method combines the benefits of exploiting the phase MR signal for contrast enhancement and the sensitivity optimization by using MR microcoils. Biochemical spectroscopy investigations were performed as well within a timeframe not detrimental for preserving cells viability.