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Abstract #0788

Studying the Effect of Different Biomaterials on Healing Process in Bone Injury Model Using Microscopic MRI and Micro CT

May Abdel Hamid Taha1, Sarah L. Manske2, Erika Kristensen3, Jaymi T. Taiani4, Roman Krawetz5, Ying Wu, Steven K. Boyd6, John Robert Matyas7, Derrick E. Rancourt5, Jeffery F. Dunn1

1Radiology, University of Calgary, Calgary, Alberta, Canada; 2Kinesiology; 3Mechanical and Manufacturing Engineering; 4 Medical Sciences; 5Departments of Oncology, Biochemistry & Molecular Biology and Medical Genetics; 6Mechanical and Manufacturing Engineering; 7Comparative Biology and Experimental Medicine in Veterinary Medicine, University of Calgary, Calgary, Alberta, Canada

The objective of this study was to investigate the effect of different biomaterials on bone healing in vivo in a mouse model of bone injury. These materials; matrigel, purecol gel and hydroxyapatite (HA) are potential matrices to support stem cells. Optimized in vivo MR microscopy and micro computed tomography were used to assess fracture repair. In addition, MRI images and CT scans were compared at the same time point, to show the difference between them in revealing the actual stage of healing.