Abstract #0801

Multi-Modality Imaging of Bone Marrow Edema-Like Lesions and Associated Cartilage in Osteoarthritic Patients

Daniel Kuo¹, Joseph Schooler¹, Janet Goldenstein¹, Sarmad Siddiqui¹, Swetha Shanbhag¹, Jean-Baptiste Pialat¹, Andrew Burghardt¹, Sharmila Majumdar¹, Michael Ries², Galateia Kazakia¹, Xiaojuan Li¹

¹Musculoskeletal Quantitative Imaging Research (MQIR), Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States; ²Department of Orthopaedic Surgery, University of California, San Francisco, San Francisco, CA, United States

Osteoarthritis (OA) is a complex disease that affects both cartilage and bone. Bone marrow edema-like lesions (BMEL) are important in studying OA, but knowledge about them is limited. In this study, we take a multi-modality imaging approach, examining MR T1 and T2 values of BMEL-associated cartilage plus structure and composition of BMEL tissue using high resolution peripheral quantitative computed tomography (HR-pQCT) imaging and Fourier transform infrared (FTIR) spectroscopy. Our results indicate that regions of BMEL are associated with more advanced cartilage degeneration and that there is a localized imbalance in bone formation and mineralization specific to BMEL regions.