Quantitative Measurement of Bone Marrow Composition and Bone Structure Using Simultaneous Acquisition of Fat Fraction and T2* with Multiple-Echo Gradient-Echo Method in the Normal Volunteers and Hematological Disease Patients

Eito Kozawa¹, Waka Mizukoshi¹, Naoko Nishi¹, Yasuo Sakurai¹, Noriko Tanaka¹, Fumiko Kimura¹

We illustrate its use for measuring lumbar spine of fat fraction and T2* in normal volunteers and malignant hematological disease patients group with multiple echo gradient echo images (MEGE). Fat fractions of MEGE vs. MR spectroscopy (MRS), and T2* vs. each group were analyzed by linear regression method and Mann-Whitney rank test. Fat fraction values of MEGE and MRS show very good agreement. T2* values vs. each group showed significant difference (p<0.05). In conclusion, MR determination of those parameters could be used to assess and diagnose a deficiency in marrow composition and bone structure using fat fraction and T2*.