Janet Goldenstein1,2, Joseph Schooler1,
Jason C. Crane1,
1Department of Radiology and Biomedical
Imaging, UC San Francisco, San Francisco, CA, United States; 2Joint
Graduate Group in Bioengineering, UC Berkeley/UC San Francisco, San
Francisco, CA, United States
scan prescription for MRI of the knee is very important for accurate
comparison and quantitative analysis of images in a longitudinal study. This
study demonstrates the feasibility of using a mutual information based method
to register MR images of the knee without segmentation and automatically
determine the follow-up scan prescription.
This registration method is performed only on the distal femur and is
not affected by the proximal tibia or soft tissues. Results show an improvement with
registration in the coefficient of variation for cartilage thickness,
cartilage volume, and T2 relaxation measurements.