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Abstract #0821

In-Vivo Assessment of Collagen Fiber Arrangement in Articular Cartilage with 7T MRI

Nikita Garnov1, Gregor Thrmer1, Wilfried Grnder2, Robert Trampel3, Robert Turner3, Thomas Kahn1, Harald Busse1

1Diagnostic and Interventional Radiology, Leipzig University Hospital, Leipzig, Germany; 2Institute of Medical Physics and Biophysics, Leipzig University, Leipzig, Germany; 3Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany

The collagen fiber network determines the biomechanical properties of articular cartilage. It has been shown that the ultrastructure of the cartilage can be assessed by means of T2-weighted high-resolution MRI in vitro. With the recent introduction of ultra-high field whole-body scanners, this approach may also be applied to human in-vivo studies. We describe a method to non-invasively assess the fiber structure of knee cartilage and present first results on three healthy volunteers at 7T. High-resolution in-vivo cartilage MRI is considered a helpful and relatively simple tool to evaluate the integrity of the collagen network and general condition.