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Abstract #0823

Biochemical MRI of Human Femoral Cartilage in Vivo: Relationships with Arthroscopic Indentation Stiffness and Defect Severity

Tuomas Svrd1, Martti Lakovaara2, Harri Pakarinen2, Ilkka Kiviranta3, Eveliina Lammentausta1, Jukka Jurvelin4, Osmo Tervonen1,5, Risto Ojala1, Miika T. Nieminen1,6

1Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland; 2Department of Orthopaedic Surgery, Oulu University Hospital, Oulu, Finland; 3Department of Orthopaedics and Traumatology, Helsinki University Hospital; 4Department of Physics, University of Eastern Finland, Kuopio, Finland; 5Department of Diagnostic Radiology, University of Oulu, Oulu, Finland; 6Department of Medical Technology, University of Oulu, Oulu, Finland

The study aimed to determine the usability of biochemical MRI methods, namely T2 relaxation time mapping and dGEMRIC, for detecting early mechanical and visually graded cartilage alterations in vivo, as determined by arthroscopic indentation stiffness measurements and arthroscopic grading, respectively, in 15 subjects. T2 and dGEMRIC values showed a trend with cartilage defect severity, however, no statistical significance was reached. Further, T2 was negatively correlated (r≈-0.6, p<0.05) with cartilage stiffness at several ROIs of the medial compartment. The results suggest that biochemical MRI measurements may be related to information on the mechanical and structural integrity of cartilage.