Matthew Fenty1, Victor Babu Kassey1, George Dodge2, Ari Borthakur1, Ravinder Reddy1
1Center for Magnetic Resonance and Optical Imaging, University of Pennsylvania School of Medicine, Philadelphia, PA, United States; 2Department of Orthopaedic Surgery, University of Pennsylvania, Philadelphia, PA, United States
T1ρ MRI is sensitive to molecular changes in cartilage, which have been shown to occur early in osteoarthritis. Dunkin-Hartley guinea pigs spontaneously develop osteoarthritis within 9 months of age. This study quantifies the age dependent degeneration of cartilage in the guinea pig stifle using T1ρ MRI with detailed correlation using histology and immunohistochemistry.