Matthew Fenty1, Victor Babu Kassey1,
George Dodge2, Ari Borthakur1, Ravinder Reddy1
1Center for Magnetic Resonance and
Optical Imaging, University of Pennsylvania School of Medicine, Philadelphia,
PA, United States; 2Department of Orthopaedic Surgery, University
of Pennsylvania, Philadelphia, PA, United States
T1ρ
MRI is sensitive to molecular changes in cartilage, which have been shown to
occur early in osteoarthritis.
Dunkin-Hartley guinea pigs spontaneously develop osteoarthritis within
9 months of age. This study quantifies the age dependent degeneration of
cartilage in the guinea pig stifle using T1ρ MRI with detailed
correlation using histology and immunohistochemistry.
Keywords