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Abstract #0837

Quantification of Age Dependent Molecular Changes in Guinea Pig OA Model Using T1ρ MRI

Matthew Fenty1, Victor Babu Kassey1, George Dodge2, Ari Borthakur1, Ravinder Reddy1

1Center for Magnetic Resonance and Optical Imaging, University of Pennsylvania School of Medicine, Philadelphia, PA, United States; 2Department of Orthopaedic Surgery, University of Pennsylvania, Philadelphia, PA, United States

T1ρ MRI is sensitive to molecular changes in cartilage, which have been shown to occur early in osteoarthritis. Dunkin-Hartley guinea pigs spontaneously develop osteoarthritis within 9 months of age. This study quantifies the age dependent degeneration of cartilage in the guinea pig stifle using T1ρ MRI with detailed correlation using histology and immunohistochemistry.