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Abstract #0860

A 31P MRS Study of the Effects of Exercise-Induced Acidosis on Phosphocreatine Recovery Kinetics in Three Muscle Groups in a Single Cohort of Human Subjects

Gwenael Layec1, Emil Malucelli2, Christophe Vilmen1, David Manners2, Kazuya Yashiro1, Claudia Testa2, Patrick J. Cozzone1, stefano Iotti2, David Bendahan1

1CRMBM UMR CNRS 6612, Marseille, France; 2Dipartimento di Medicina Interna, dellInvecchiamento e Malattie Nefrologiche; Universit di Bologna, Italy

It is acknowledged that mitochondrial function can be assessed in vivo from PCr resynthesis during recovery period. Several studies have pointed out that end-of-exercise conditions could bias the characterization of mitochondrial function. The purpose of the present study was to analyze the relationship between end-of-exercise pH and PCr recovery rates in forearm, calf and thigh muscles in a single group of subjects in order to determine whether a common normalisation frame could be adopted for different muscles. Overall, our results clearly illustrate that, whatever the muscle investigated, low end-of exercise pH is systematically related to a slower PCr recovery kinetics.