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Abstract #0862

Localised Versus Unlocalised Dynamic 31P MRS Acquisition in Exercising Human Muscle at 7T

Martin Meyerspeer1,2, Ewald Unger1, Thomas Mandl1,2, Tom Scheenen3, Graham J. Kemp4, Ewald Moser, 2

1Center for Biomedical Technology and Physics, Vienna Medical University, Vienna, Austria; 2High Field MR Centre of Excellence, Vienna Medical University, Vienna, Austria; 3Dpt. of Radiology, Radboud University, Nijmegen, Netherlands; 4School of Clinical Science, Faculty of Medicine, University of Liverpool, Liverpool, United Kingdom

The effect of localised versus non-localised 31P MRS on data acquired from aerobically exercising human gastrocnemius muscle is studied at ultra hight field. For localisation, a short TE single voxel spectroscopy MR sequence comprising adiabatic refocussing which allows high temporal resolution is used. From a series of exercise bouts of equal intensity we conclude that with localisation, PCr is depleted to a lower level, recovery from depletion is faster and no compartmentation of pH, manifest in a spliting of the Pi peak is observed, in contrast to non-localised 31P MRS.