Abstract #0868

Effect of Cholecalciferol Supplementation on Muscle Strength in Healthy Volunteers with Low Serum 25(OH)D: A Double Blind Randomized Placebo Controlled Trial

Rajat Gupta¹, Uma Sharma², Nandita Gupta¹, U Singh³, Randeep Guleria⁴, Naranamangalam R. Jagannathan², Ravinder Goswami¹

¹Department of Endocrinology, All India Institute of Medical Sciences, New Delhi, Delhi, India; ²Department of NMR & MRI Facility, All India Institute of Medical Sciences, New Delhi, Delhi, India; ³5Department of Physical Medicine and Rehabilitation, All India Institute of Medical Sciences, New Delhi, Delhi, India; ⁴Department of Medicine, All India Institute of Medical Sciences, New Delhi, Delhi, India

Effects of six months cholecalciferol and calcium supplementation was investigated on the skeletal muscle strength and muscle energy metabolism using 31PMRS in healthy volunteers with low serum 25(OH)D in a double blind randomized placebo controlled trial. At six months, 25(OH)D levels, hand grip strength, gastrosoleus muscle strength, distance covered during six minute walk were significantly higher in cholecalciferol compared to placebo group (p=0.001). There were no significant differences in MIP, MEP and PCr/Pi ratio in the two groups at six months. Thus, improvement in muscle strength could be due to factors other than change in muscle energy metabolism.