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Abstract #0885

High Resolution Diffusion Tensor MRI of Rabbit Tendons and Ligaments at 11.7T

Aman Gupta1,2, Weiguo Li1, Glenn T. Stebbins1,3, Richard L. Magin1, Vincent M. Wang1,2

1Department of Bioengineering, University of Illinois at Chicago, Chicago, IL, United States; 2Department of Orthopedic Surgery, Rush University Medical Center, Chicago, IL, United States; 3Department of Neurosciences, Rush University Medical Center, Chicago, IL, United States

Low grade tendon and ligament injuries are challenging to delineate on conventional MRI. This study presents results of 11.74T DTI analyses of rabbit MCL ligament and SemiT tendon. FA and MD(x10-6 mm2/s) values for SemiTs (n=6) were 0.66 and 1388, respectively, and for MCLs (n=4) were 0.47 and 1255. 3D tractography graphically depicted the spatial distribution of parallel, well organized collagen bundles. To our knowledge, this is the first study that investigates the microstructure of these tissue types using 3D DTI at high magnetic field. High Field DTI provides more rigorous data regarding tissue structural integrity compared to conventional MRI.