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Abstract #0933

Early Metabolic Changes of Mild Traumatic Brain Injury Revealed by 3D MRSI at 3T

Duan Xu1,2, Natalie Charlton1, Srivathsa Veeraraghavan1, Geoffrey T. Manley3, Pratik Mukherjee1,2

1Dept of Radiology, UCSF, San Francisco, CA, United States; 2UCSF/UC Berkeley Joint Graduate Group in Bioengineering, San Francisco and Berkeley, CA, United States; 3Dept of Neurosurgery, UCSF, San Francisco, CA, United States

Conventional MR imaging does not accurately predict outcome in mild TBI, but MR diffusion and proton spectroscopy has shown promise as potential biomarkers for injury severity and long-term neurocognitive and functional outcome. In this study, we utilized 3D MRSI at 3T with wide anatomic coverage to assess TBI in specific association, commissural, and projection white matter tracts.