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Abstract #0951

In Vivo Temperature Brain Map Using Jmrui V4.X: A Plugin Development

Elena Vescovo1, Federico Di Cesare2, Dan Stefan2, Danielle Graveron-Demilly2, Steve Williams3

1Image Science and Biomedical Engineering,, The University of Manchester, Manchester, Greater Manchester, United Kingdom; 2Laboratoire CREATIS-LRMN, CNRS UMR 5220, Universite' Claude Bernard Lyon 1, Lyon, France; 3Image Science and Biomedical Engineering, The University of Manchester, Manchester, Greater Manchester, United Kingdom

Magnetic resonance spectroscopy can provide a non-invasive approach to measure the internal temperature of the brain; it relies on the linear relationship between the 1H MR resonance frequency of water in the tissue and the tissues temperature. The absolute temperature is obtained by measuring the chemical shift of water relative to a reference compound such as N-Acetylaspartate (NAA). To convert the frequency difference between these two signals into temperature, it is necessary to apply a calibration curve. All these procedures could be performed using a plugin of jMRUI, a Java-based Graphical User Interface that allows time-domains analysis of MRS, MRSI and HRMS-NMR signals. In this work we used jMRUI v4.x, a new version of the software that enabled the user to add their own plugin.