Chin-Yu Lu1, Yi-Ru Lin2, Stefan Posse3,4, Shang-Yueh Tsai5
1Biomedical Engineering, National Taiwan University of Science and Technology, Taipei, Taiwan; 2Eletronic Engineering, National Taiwan University of Science and Technology, Taipei, Taiwan; 3Department of Neurology, University of New Mexico School of Medicine, Albuquerque, Albuquerque, New Mexico 87131, United States; 4Electrical and Computer Engineering Department, University of New Mexico, Albuquerque, NM, United States; 5Electrical Engineering, Chang Gung University, Taoyuan, Taiwan
Previous dsrPEPSI study which measured glutamate (Glu) shown the feasibility to reduce scan time from 16 mins to 1min. However, as scan time reduced, the SNR decreased and poor spectra qualities were observed. This study conducted to investigate and optimize the spectra quality versus scan time by tuning the arrangement of radial trajectories and TEs. From our result, 4-fold dsrPEPSI is feasible to acquire Glu at a 3T system while maintaining spectral quality. And the scan time was 4 minutes, which was a reasonable length for clinical use.