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Abstract #0990

Drug Distribution Imaging of Anticancer Drug 5-FU Using 19F/1H Double-Tuned RF Coil

Yosuke Otake1, Koji Hirata1, Yoshihisa Soutome1, Yoshitaka Bito1

1Central Research Laboratory, Hitachi, Ltd., Kokubunji, Tokyo, Japan

Imaging of 19F-labeled drug distribution was demonstrated using a developed 19F/1H double-tuned RF coil and anticancer drug 5-FU administered rats. Fast spin echo with frequency selective pulses was used to efficiently obtain distribution images of 5-FU, its active anabolites, and its catabolites at the same time. The spatial change in signal intensity among several organs and tissue in images may be used to analyze the pharmacokinetics. The developed double-tuned RF coil will be a powerful tool for 19F-labeled compounds distribution imaging and pharmacokinetics research.