Wei Chen1, Joseph R. DiFranza2, Jean King3
1Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA, , United States; 2Department of Family Medicine and Community Health,, University of Massachusetts Medical School, Worcester; 3Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA, United States
Tobacco dependence is the most preventable cause of death. Varenicline is a partial nicotinic receptor agonist/antagonist that is widely used as a smoking cessation aid. How varenicline helps smokers is unknown. We sought to compare the brain Blood oxygenation level dependent (BOLD) activation produced by a high dose varenicline to a lower dose varenicline in awake nave animals, which hopes to assist in understanding the action of this partial nicotinic receptor agonist/antagonist in patients.