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Abstract #1074

Long Term Vascular Access Ports as a Means of Sedative Administration in a Rodent FMRI Survival Model

Patrick C. Hettinger1, Rupeng Li2, Ji-Geng Yan1, Hani S. Matloub1, Young R. Cho1, Matthew L. Runquist2, Christopher P. Pawela1,2, James S. Hyde2

1Plastic Surgery, Medical College of Wisconsin, Milwaukee, WI, United States; 2Biophysics, Medical College of Wisconsin, Milwaukee, WI, United States

The purpose of this study is to develop a rodent survival model that enables fMRI at multiple time-points under sedation. In this study, 9 Sprague-Dawley rats underwent surgical placement of a long-term vascular access port. The animals were then imaged using fMRI during nerve stimulation at 1 week, 3 weeks, and 5 weeks post-operatively. During imaging, all animals breathed spontaneously while intravenous sedative was administered through the port. To date, all animals have successfully been imaged at each time-point. All vascular access ports have remained patent, making these devices a viable option for longitudinal MRI studies requiring venous access.