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Abstract #1091

Development and Evaluation of Alternative Imaging Methods for FMRI at 7 Tesla

John Sexton1,2, Jascha Swisher3, Frank Tong3, Baxter Rogers1,2, J Christopher Gatenby1,4, John C. Gore1,4

1Vanderbilt University Institute of Imaging Science, Nashville, TN, United States; 2Biomedical Engineering, Vanderbilt University, Nashville, TN, United States; 3Psychology, Vanderbilt University, Nashville, TN, United States; 4Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, United States

We compare single-shot gradient-echo 2D-EPI, multi-shot gradient-echo 3D-FFE and multi-shot gradient-echo 3D-PRESTO in a polar angle retinotopic mapping experiment at four isotropic resolutions (1.12mm3, 1.67mm3, 2mm3, and 3mm3) at 7 Tesla. Retinotopic maps in agreement with literature were obtained at all resolutions. The 3D sequences provided similar BOLD sensitivity and significantly less distortion compared to 2D-EPI. In addition, 3D-PRESTO provided much higher temporal resolution than 2D-EPI. Our findings suggest rich potential for high-resolution 3D imaging sequences in retinotopic mapping and other functional MRI experiments at high field.