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Abstract #1098

Simultaneous Optical Tomography (OT) and FMRI with and Without Task Activation

Jan Mehnert1,2, Christoph Schmitz2,3, Harald E. Mller1, Hellmuth Obrig1,2, Karsten Mller1

1Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany; 2Berlin Neuroimaging Center, Charit University Hospital Berlin, Berlin, Germany; 3NIRx Medizintechnik GmbH, Berlin, Germany

Correlation analysis of low-frequency fluctuations in blood-oxygen level dependent (BOLD) fMRI data is known to yield functional connectivity maps. The procedure, also referred to as resting-state connectivity, has previously been applied to optical tomography (OT) data using dense probe arrays. Here, we assess whether a sparser topographical sampling still yields results that are comparable to the gold standard of resting-state network assessment, i.e. fMRI. In a first step, we used a subset of optical fibers (2-3cm inter-optode distance) covering both motor cortices and combined OT with concurrent fMRI measurements to cross-validate our resting-state data analysis.