Jan Mehnert1,2,
Christoph Schmitz2,3, Harald E. Mller1, Hellmuth Obrig1,2,
Karsten Mller1
1Max Planck Institute for Human
Cognitive and Brain Sciences, Leipzig, Germany; 2Berlin
Neuroimaging Center, Charit University Hospital Berlin, Berlin, Germany; 3NIRx
Medizintechnik GmbH, Berlin, Germany
Correlation
analysis of low-frequency fluctuations in blood-oxygen level dependent (BOLD)
fMRI data is known to yield functional connectivity maps. The procedure, also
referred to as resting-state connectivity, has previously been applied to
optical tomography (OT) data using dense probe arrays. Here, we assess
whether a sparser topographical sampling still yields results that are comparable
to the gold standard of resting-state network assessment, i.e. fMRI. In a
first step, we used a subset of optical fibers (2-3cm inter-optode distance)
covering both motor cortices and combined OT with concurrent fMRI
measurements to cross-validate our resting-state data analysis.
Keywords