Abstract #1111

Reproducibility of T1 and Tissue Fractional Volume Mapping Using FRASIER: An Application to FMRI Settings

Wanyong Shin¹, Hong Gu¹, Yihong Yang¹

¹Neuroimaging Research Branch, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, United States

Recently, FRActional Signal mapping from InvErsion Recovery (FRASIER) was proposed to map T1 and tissue fractional volume in the brain. In this study we incorporated FRASIER into an fMRI protocol and assessed the reproducibility of the technique. Using FRASIER, 15 slice T1 and fractional volume maps were acquired in every 10 seconds with 6464 matirx size. Standard deviations of the T1 and fractional volume maps was within 37ms and 3.5% in this study, demonstrating feasibility of FRASIER in fMRI settings.