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Abstract #1113

An EEG Homologue of the Negative BOLD Response as Measured at 7 Tesla

Wietske van der Zwaag1,2, Marzia De Lucia3, Nadine Graedel2, Micah M. Murray3, Rolf Gruetter1,2

1Radiologie, Universit de Lausanne, Lausanne, Vaud, Switzerland; 2CIBM, EPFL, Lausanne, Vaud, Switzerland; 3Electroencephalography Brain Mapping core, CHUV, Lausanne, Vaud, Switzerland

The basis of fMRI experiments is a tight coupling of neural activity with the BOLD response in both space and time. However, cross-modal negative BOLD signal may also be caused by blood-steal effects. Here, we measure the negative BOLD signal using ultra-high field fMRI and the neuroelectrical activity as measured by EEG in the same subjects. Neural deactivation is found in the EEG-based electrical neuroimaging maps in regions partially overlapping with those where the negative BOLD signal is found, implying a possible neural basis for the negative BOLD response.