Wietske
van der Zwaag1,2, Marzia De Lucia3, Nadine Graedel2,
Micah M. Murray3, Rolf Gruetter1,2
1Radiologie,
Universit de Lausanne, Lausanne, Vaud, Switzerland; 2CIBM, EPFL,
Lausanne, Vaud, Switzerland; 3Electroencephalography Brain Mapping
core, CHUV, Lausanne, Vaud, Switzerland
The
basis of fMRI experiments is a tight coupling of neural activity with the
BOLD response in both space and time. However, cross-modal negative BOLD
signal may also be caused by blood-steal effects. Here, we measure the
negative BOLD signal using ultra-high field fMRI and the neuroelectrical
activity as measured by EEG in the same subjects. Neural deactivation is
found in the EEG-based electrical neuroimaging maps in regions partially
overlapping with those where the negative BOLD signal is found, implying a
possible neural basis for the negative BOLD response.
Keywords