Abstract #1116

Hemodynamic Response Function (HRF) Modulation by Inhaled CO2 Concentration Using Event-Related FMRI

Chao-Chun Lin^1,2, Yi-Jui Liu^3,4, Chien-Kuo Chen³, Hsiao-Wei Peng³, Kuo-Fang Shao⁴, Wu-Chung Shen^1,5, Chang Hing-Chiu⁶

¹Department of Radiology, China Medical University Hospital, Taichung, Taiwan, Taiwan; ²Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan, Taiwan; ³Department of Automatic Control Engineering, Feng Chia University, Taichung, Taiwan; ⁴Master's Program in Biomedical Informatics and Biomedical Engineering, Feng Chia University, Taichun, Taiwan; ⁵School of Medicine, China Medical University, Taichung, Taiwan; ⁶Applied Science Laboratory, GE Healthcare Taiwan, Taipei, Taiwan

The purpose of this study was to evaluate the hemodynamic response function (HRF) change after inhalation of different carbon dioxide concentrations. Using event-related method investigate the transient hemodynamic response function by short-time visual stimulus with different CO2 concentrations. Our results show that the peak of HRF curve is decreased and delayed with increased inhaled CO2 concentrations, and the width of HRF curve is wider with higher inhaled CO2 concentration.