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Abstract #1123

Whole-Brain Mapping of Venous Vessel Size in Humans Using the Hypercapnia-Induced BOLD Effect

Thies Halvor Jochimsen1,2, Dimo Ivanov2, Derek V M Ott2, Wolfgang Heinke3, Robert Turner2, Harald E. Mller2, Jrgen R. Reichenbach1

1Medical Physics Group, Department of Diagnostic and Interventional Radiology, Jena University Hospital, Jena, Germany; 2Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany; 3Department of Anesthesiology and Intensive Care Medicine, University of Leipzig, Medical Faculty, Leipzig, Germany

It is demonstrated that non-invasive mapping of the venous microstructure (vessel radius) is possible by using the hypercapnia-induced BOLD effect. Furthermore, it is shown that maps of venous blood volume and vessel density can be obtained from the same experimental setup. These parameters are important for characterizing tumor angiogenesis and type.