Jochimsen1,2, Dimo Ivanov2, Derek V M Ott2,
Wolfgang Heinke3, Robert Turner2, Harald E. Mller2,
Jrgen R. Reichenbach1
1Medical Physics Group, Department of
Diagnostic and Interventional
Radiology, Jena University Hospital, Jena, Germany; 2Max
Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany; 3Department
of Anesthesiology and Intensive Care Medicine, University of Leipzig, Medical
Faculty, Leipzig, Germany
is demonstrated that non-invasive mapping of the venous microstructure
(vessel radius) is possible by using the hypercapnia-induced BOLD effect.
Furthermore, it is shown that maps of venous blood volume and vessel density
can be obtained from the same experimental setup. These parameters are
important for characterizing tumor angiogenesis and type.