Fan Wang1, Claire Stevenson1,
Matthew Brookes1, Peter Morris1
1Physics, Sir Peter Mansfield Magnetic
Resonance Centre, Nottingham,
use the combination of MEG and fMRI to study the neural basis for BOLD
non-linearity. Both nonlinear neural responses to stimuli and nonlinear
vascular responses to neural activity may contribute to BOLD non-linearity
and the relative contribution of these two effects remains poorly understood.
We extended the study of non-linear neural response to both phase locked
evoked response and time related beta oscillations in somatosensory cortex.
The N20 peak amplitudes show non-linearities with ISI of 0.25-2s, influenced
by beta power at the time of stimulation, suggesting that best oscillation
should also be considered for BOLD convolution.