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Abstract #1125

Linearity of Neural Responses in the Somatosensory Cortex and Their Relationship to BOLD FMRI.

Fan Wang1, Claire Stevenson1, Matthew Brookes1, Peter Morris1

1Physics, Sir Peter Mansfield Magnetic Resonance Centre, Nottingham, Nottinghamshire, United Kingdom

We use the combination of MEG and fMRI to study the neural basis for BOLD non-linearity. Both nonlinear neural responses to stimuli and nonlinear vascular responses to neural activity may contribute to BOLD non-linearity and the relative contribution of these two effects remains poorly understood. We extended the study of non-linear neural response to both phase locked evoked response and time related beta oscillations in somatosensory cortex. The N20 peak amplitudes show non-linearities with ISI of 0.25-2s, influenced by beta power at the time of stimulation, suggesting that best oscillation should also be considered for BOLD convolution.