Xiaopeng Zong1, Jie Huang1,2
1Department of Radiology, Michigan State University, East Lansing, MI, United States; 2Neuroscience Program, Michigan State University, East Lansing, MI, United States
A quantitative ER-fMRI study requires to measuring hemodynamic response function (HRF) both accurately and precisely. A periodic ER-fMRI design can produce a high accuracy of HRF measurement but a low precision. Utilizing the approximate linearity of the HRF, a rapid-presentation (RP) ER-fMRI design can improve the precision by shorting intersitimulus interval (ISI). Nevertheless, hemodynamic response is non-linear and its corresponding effect on the estimated HRF increases with decreasing ISI, rendering the estimated HRF inaccurate for small ISI values. Accordingly, as demonstrated in this preliminary study, an optimal RP ER-fMRI design should maximize both accuracy and precision of HRF measurements.