Xiaopeng Zong1, Jie Huang1,2
1Department of Radiology, Michigan
State University, East Lansing, MI, United States; 2Neuroscience
Program, Michigan State University, East Lansing, MI, United States
A
quantitative ER-fMRI study requires to measuring hemodynamic response
function (HRF) both accurately and precisely. A periodic ER-fMRI design can
produce a high accuracy of HRF measurement but a low precision. Utilizing the
approximate linearity of the HRF, a rapid-presentation (RP) ER-fMRI design
can improve the precision by shorting intersitimulus interval (ISI).
Nevertheless, hemodynamic response is non-linear and its corresponding effect
on the estimated HRF increases with decreasing ISI, rendering the estimated
HRF inaccurate for small ISI values. Accordingly, as demonstrated in this
preliminary study, an optimal RP ER-fMRI design should maximize both accuracy
and precision of HRF measurements.
Keywords