Clarisse Ildiko Mark1, M. Slessarev2,
1McConnell Brain Imaging Center,
Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada;
2Department of Anaesthesiology, University Health Network,
Univeristy of Toronto,, Toronto, Ontario, Canada; 3Department of
Anaesthesiology and Medical Crisis Management, Nagoya City University
Graduate School of Medical Sciences, Nagoya, Japan
Manual
HC calibration depends on intrinsically low signal-to-noise perfusion imaging
and individual vascular architecture, with resulting calibration (M)-values
prone to large intra- and inter-subject variations that may bias oxygen
metabolism studies. We thereby sough
to investigate HO as a calibration alternative under rigorous control of
end-tidal partial pressures of CO2 (PetCO2) and O2
(PetO2). Our findings
suggest the viability of precisely controlling HO stimulation to provide more
precise per-subject and per-brain-region M-estimates, based on high SNR PaO2
measurements and the removal of the confound of vascular variation in
population observed under HC-calibration.
Keywords