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Abstract #1154

A Statistical Method for Computing BOLD Activations in Multi-Echo Time FMRI Data Sets and Identifying Likely Non-BOLD Task Related Signal Change

Andrew Scott Nencka1, Daniel L. Shefchik1, James S. Hyde1, Andrzej Jesmanowicz1, Daniel B. Rowe2

1Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI, United States; 2Department of Mathematics, Statistics and Computer Science, Marquette University, Milwaukee, WI, United States

The T2* contrast mechanism associated with the BOLD signal is well known, as is its echo time (TE) dependence. In this abstract, we present a method for analyzing data acquired with interleaved echo times. Based upon the expected BOLD TE behavior, the ratio of the regression coefficients for the task related columns of the design matrix may be used to identify voxels which exhibit BOLD-like responses.