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Abstract #1169

Functional Connectivity During Memory Consolidation: A Resting-State FMRI Study

Chia-Wei Li1, Ke-Hsin Chen2, Tai-Li Chou2,3, Keng-Chen Liang2,3, Ya-Chih Yu1, Chang-Wei Wu1, Jy-Horng Chen1,3

1Department of Electrical Engineering, National Taiwan University, Taipei, Taiwan, Taiwan; 2Department of Psychology, National Taiwan University, Taipei, Taiwan; 3Center for Neurobiology and Cognitive Science, National Taiwan University, Taipei, Taiwan

Memory consolidation is a process which stabilizes a short-term memory into a long-term memory. Consolidation occurs after the initial learning lasting for a period of time. In this study, we employed resting-state experiment design to reveal the functional connectivity among hippocampus, PCC, and MTG during consolidation of memorizing easy and difficult words that would result in good and poor memory respectively. As seeds set at three ROIs, we detected increase connection with cuneus in the hard condition, implying the engagement of visual analysis; increment in connection with cerebellum and frontal cortex in the easy condition, reflecting the on-going consolidated activity.