Marco Pimentel1, Pedro Vilela2, Ins Sousa3,4, Patricia Figueiredo3
1Faculdade de Cincias e Tecnologia, Universidade Nova de Lisboa, Lisbon, Portugal; 2Imaging Department, Hospital da Luz, Lisbon, Portugal; 3Instituto Superior Tcnico, Lisbon, Portugal; 4Healthcare Sector, Siemens, S.A., Portugal
Previous studies have shown that ASL-based fMRI exhibits better spatial specificity than the most commonly used BOLD contrast. Here, we compared the localization of the hand motor area obtained by simultaneous ASL-BOLD fMRI and standard BOLD fMRI at 3T with well established anatomical landmarks, in a group of 15 healthy subjects. Our results indicate that the localization of the hand motor area obtained using ASL fMRI is significantly less variable and closer to the hand motor cortex anatomical landmarks than the one produced by BOLD fMRI. This supports the notion that ASL may more accurately localize brain activation than BOLD.