Abstract #1186

An FMRI Study of Memory Performance in Type 2 Diabetes Mellitus: A Twin Study

Amanda Wood¹, Jian Chen^2,3, Thanh G. Phan², Kimberlea Cooper², Stacey Litras², Srikanth Velandai²

¹Developmental and Functional Brain Imaging,Critical Care and Neuroscience, Murdoch Childrens Research Institute, Melbourne, VIC, Australia; ²Stroke and Ageing Research Group, Department of Medicine, Monash University, Melbourne, VIC, Australia; ³Developmental and Functional Brain Imaging,Critical Care and Neuroscience , Murdoch Childrens Research Institute, Melbourne, VIC, Australia

Type 2 Diabetes mellitus (DM) is linked to a greater risk of dementia, but the underlying mechanisms and brain regions involved are unknown. We conducted a co-twin (DM/non DM) case-control study of fMRI activation during a visual memory task. Non DM twins showed greater activation of temporal, parietal and occipital cortices suggesting involvement of these areas in DM pathology.