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Abstract #1218

fMRI at 17.6 T and Optical Fiber-Based Ca2+-Imaging in Rodents

Albrecht Stroh1, Florian Schmid2, Afra Wohlschlaeger3, Valentin Riedl4, Jenny Kressel3, Cornelius Faber2

1Department of Neuroradiology, Technical University Munich, Munich, Germany; 2Institute for Clinical Radiology, University Hospital Mnster, Mnster, Germany; 3Department of Neuroradiology, Technical University Munich, Germany; 4Department of Neurology, Technical University Munich, Germany

n this study we tested the feasibility of rat fMRI at highest field strength in combination with an implanted optical fiber. We aim for the combination of fiber based optical Ca2+ imaging with functional magnetic resonance imaging (fMRI) at 17.6 T in vivo. We increased the temporal resolution of fMRI to 20 ms by applying k-space segmentation. Additionally, we conducted fiber-based Ca2+ imaging in mice upon electric forepaw stimulation, detecting neuronal population activity. Our study indicates that a multimodal approach combining a global method like fMRI with a spatially confined, highly specific method as optical Ca2+ imaging becomes amenable.