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Abstract #1294

Three-Compartment Pharmacokinetic Modeling of Chronic Myocardial Infarction Gadolinium Kinetics

James W. Goldfarb1,2, Wenguo Zhao1

1Saint Francis Hospital, Roslyn, NY, United States; 2Program in Biomedical Engineering, Stony Brook University, Stony Brook, NY, United States

The aim of this study was to investigate the suitability of a three compartment pharmacokinetic model of late gadolinium-enhancement for chronic myocardial infarcts. Twenty-five individuals with chronic myocardial infarctions (MI) underwent MR imaging at 1.5T. Blood concentration was modeled with a bi-exponential and tissue concentration with a three compartment model, including vascular, free and trapping compartments. Fractional volumes and transfer constants into the compartments were fitted parameters of the model. It was found that a three compartment model is suitable for detailed modeling of chronic MI Gd-pharmacokinetics. This model provides further justification that fibrosis traps the Gd-contrast agent while Gd-concentrations in the free extracellular matrix remain similar with viable myocardium.