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Abstract #1320

The Effects of Fasting on Myocardial Lipid Content in Fatty Acid β-Oxidation Deficient Mice Studied with in Vivo 1H-MRS

Adrianus Johannes Bakermans1, Sander M. Houten2, Tom R. Geraedts1, Michel van Weeghel2, Klaas Nicolay1, Jeanine J. Prompers1

1Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands; 2Laboratory Genetic Metabolic Diseases, Academic Medical Centre, Amsterdam, Netherlands

A respiratory gated, cardiac triggered PRESS 1H-MRS sequence was used to investigate effects of fasting on lipid content in the long chain acyl-coenzyme A dehydrogenase knockout (LCAD-/-) mouse heart. Left ventricular (LV) function and morphology were assessed using cine MRI. LV mass normalized to body weight was larger in LCAD-/- mice than in controls, indicating LV hypertrophy. There was a trend for a decrease in ejection fraction after fasting, accompanied by increased lipid content in LCAD-/- mice compared to controls. It remains to be established whether there is a causal relationship between increased myocardial lipid content and decreased cardiac function.