Chia-Ying Liu1, Alban Redheuil1,
Elzbieta Chamera1, Joao Lima1, David Bluemke2,
Shenghan Lai3
1Department of Radiology, Johns Hopkins
Hospital, Baltimore, MD, United States; 2Radiology and Imaging
Sciences, National Institutes of Health, Bethesda, MD, United States; 3Department
of Epidemiology, Johns Hopkins School of Hygiene and Public health, Baltimore,
MD, United States
The
increased myocardial triglyceride pool is associated with impaired myocardial
function in animal experiments. Human studies also indicate that myocardial
steatosis is associated with impaired left ventricular filling dynamics and
diastolic dysfunction. Proton Magnetic Resonance Spectroscopy (1H-MRS) has
proven to be reliable and reproducible in measuring myocardial triglyceride
content in humans. The primary goal of the present study was to evaluate the
myocardial fat content in cardiovascularly asymptomatic HIV infected and
non-infected individuals using 1H-MRS, and to correlate the septal
triglyceride content to the regional ventricular function measured by tagged
MRI.