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Abstract #1323

Myocardial Steatosis Is Associated with Regional Ventricular Dysfunction

Chia-Ying Liu1, Alban Redheuil1, Elzbieta Chamera1, Joao Lima1, David Bluemke2, Shenghan Lai3

1Department of Radiology, Johns Hopkins Hospital, Baltimore, MD, United States; 2Radiology and Imaging Sciences, National Institutes of Health, Bethesda, MD, United States; 3Department of Epidemiology, Johns Hopkins School of Hygiene and Public health, Baltimore, MD, United States

The increased myocardial triglyceride pool is associated with impaired myocardial function in animal experiments. Human studies also indicate that myocardial steatosis is associated with impaired left ventricular filling dynamics and diastolic dysfunction. Proton Magnetic Resonance Spectroscopy (1H-MRS) has proven to be reliable and reproducible in measuring myocardial triglyceride content in humans. The primary goal of the present study was to evaluate the myocardial fat content in cardiovascularly asymptomatic HIV infected and non-infected individuals using 1H-MRS, and to correlate the septal triglyceride content to the regional ventricular function measured by tagged MRI.