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Abstract #1326

In Vivo T1 Mapping of 31P Metabolites at Short TR

Mahon L. Maguire1, Hannah Barnes1, Stefan Neubauer1, Jurgen E. Schneider1

1Dept Cardiovascular Medicine, University of Oxford, Oxford, Oxon, United Kingdom

Quantitation of the energetics of the heart requires accurate tissue specific T1 values for the 31P metabolites involved. Acquisition of 31P spectroscopic data at high resolution necessitates the use of a short TR relative to the T1 of the metabolites. High resolution 31P chemical shift imaging was employed to take spatially resolved 2, 3 and 4 flip angle T1 measurements. Phantom studies are presented investigating the optimal parameters for T1 mapping in vivo. A dual angle T1 measurement employing flip angles of 30 and 15 is optimal where TR/T1<0.2; its application in the mouse is presented.