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Abstract #1380

Multicenter Intraindividual Comparison of Gadobenate Dimeglumine and Gadofosveset Trisodium for MR Angiography of the Renal Arteries

Gunther Schneider1, Mieczyslaw Pasowicz2, Josef Vymazal3, Zdenek Seidl4, Manuela Aschauer5, Deniz Bilecen6, Roberto Iezzi7, Claudio E M Ballarati8

1Radiology, University Hospital Hamburg, Hamburg/Saar, Germany; 2Diagnostics and Rehabilitation, John Paul II Hospital, Krakow, Poland; 3Radiology, Na Homolce Hospital, Prague, Czech Republic; 4Radiology, Lkarsk Fakulta Neurologicka Klinika, Prague, Czech Republic; 5Medical University of Graz, Graz, Austria; 6Radiology, University Hospital Basel, Switzerland; 7Radiology, Universit G. D'Annunzio, Chieti, Italy; 8Radiology, Hospital Valduce, Como, Italy

In a prospective comparison of the efficacy and safety of gadobenate dimeglumine vs the intravascular blood pool agent gadofosveset trisodium for contrast-enhanced MR angiography (CE-MRA) of the renal arteries in 38 subjects, blinded experts consistently found first-pass CE-MRA after gadobenate dimeglumine to be superior to CE-MRA after gadofosveset in terms of sensitivity, specificity, accuracy, PPV, and NPV. Steady state images obtained following gadofosveset administration provided no additional diagnostic benefit in this study.