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Abstract #1391

Spontaneous Cervical Artery Dissection: An Inflammatory Disease? Results of a Prospective Observational PET-CT and MRI Study

Tobias Saam1, Thomas Pfefferkorn2, Maximilian Habs1, Marcus Hacker3, Axel Rominger3, Clemens C. Cyran1, Martin Dichgans2, Maximilian F. Reiser1, Konstantin Nikolaou1

1Clinical Radiology, University of Munich, Munich, Bavaria, Germany; 2Neurology, University of Munich, Munich, Bavaria, Germany; 3Nuclear Medicine, University of Munich, Munich, Bavaria, Germany

Spontaneous cervical artery dissection (sCAD) is a frequent cause of ischemic stroke in young adults. The pathogenesis of sCAD is poorly understood. The aim of this study was to use PET/CT and MRI to estimate the prevalence of perivascular inflammation in sCAD. This study demonstrates that inflammatory changes at the site of the arterial dissection are common in sCAD patients. In a subset of these patients, perivascular inflammation was not confined to the site of the dissection, suggesting that vessel wall inflammation might play a role in the pathogenesis of sCAD.