Abstract #1423

Visualization of Tumor Angiogenesis in Lung Cancer Overexpressing Different VEGF Isoform in a Murine Xenograft Model by Using High Resolution 3Dimentional Contrast-Enhanced Microscopic MR Angiography

Chia-Ming Shih^1,2, Ang Yuan³, Chih-Yuan Chen², Cheng-Hung Chou², Hao-Wei Cheng³, Pan-Chyr Yang³, Jyh- Horng Chen¹, Chen Chang²

¹Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan; ²Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan; ³National Taiwan University Hospital, Taipei, Taiwan

Evaluation of the different effects of VEGF isoforms such as VEGF121, VEGF165 and VEGF189 on tumor feeding vessels and intratumor vessels may offer important new insight into the process of tumor angiogenesis in non-small cell lung cancer. This study was aimed to visualize tumor angiogenesis induced by different VEGF isoform in non-small cell lung cancer in a murine xenograft model by using High Resolution 3Dimentional Contrast Enhanced- Microscopic MR Angiography (HR 3D CE-mMRA).