Meeting Banner
Abstract #1423

Visualization of Tumor Angiogenesis in Lung Cancer Overexpressing Different VEGF Isoform in a Murine Xenograft Model by Using High Resolution 3Dimentional Contrast-Enhanced Microscopic MR Angiography

Chia-Ming Shih1,2, Ang Yuan3, Chih-Yuan Chen2, Cheng-Hung Chou2, Hao-Wei Cheng3, Pan-Chyr Yang3, Jyh- Horng Chen1, Chen Chang2

1Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan; 2Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan; 3National Taiwan University Hospital, Taipei, Taiwan

Evaluation of the different effects of VEGF isoforms such as VEGF121, VEGF165 and VEGF189 on tumor feeding vessels and intratumor vessels may offer important new insight into the process of tumor angiogenesis in non-small cell lung cancer. This study was aimed to visualize tumor angiogenesis induced by different VEGF isoform in non-small cell lung cancer in a murine xenograft model by using High Resolution 3Dimentional Contrast Enhanced- Microscopic MR Angiography (HR 3D CE-mMRA).