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Abstract #1434

Accelerated High-Resolution 3D Magnetic Resonance Angiography Using SENSE: Fast and Accurate Assessment of Carotid Artery Stenosis in ApoE Ko Mice

David Ratering1, Christof Baltes1, Christine Lohmann2, Christian M. Matter2, Markus Rudin1,3

1Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland; 2Institute of Physiology, University Zurich and Cardiology University Hospital Zurich, Zurich, Switzerland; 3Institute of Pharmacology & Toxicology, University Zurich, Zurich, Switzerland

High-resolution magnetic resonance angiography (MRA) enables detection and monitoring of atherosclerosis in mouse models of human disease. However, high-resolution MRA suffers from long acquisition times putting high demands on the animals physiological stability. Therefore the feasibility of accelerated MRA of murine supra-aortic vasculature using SENSE was investigated with regard to lesion detection and quantitative morphometric analysis. Evaluations revealed that data collection with acceleration factors R ≤ 3.3 had only minor effects on vessel delineation. No significant differences could be found for the morphometric assessment of stenotic lesions and the determination of degree of stenosis when comparing accelerated to fully-sampled data.