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Abstract #1437

Realtime Cine MRI in Mice with a Single-Shot EPI Sequence and the KarhunenLoeve Transform

Guangping Dai1, Yu Ding2, Shuning Huang1, Orlando P. Simonetti2, David E. Sosnovik3

1Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School; 2Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University; 3Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States


Realtime cine MRI of the mouse heart is reported using a single-shot EPI sequence and the KarhunenLoeve transform. The entire mouse heart can be imaged with this technique in less than 5 minutes, using minimal sedation. This report demonstrates the ability of MRI to be used for high-throughput applications, and compete with echocardiography, in the basic science as well as and clinical settings.