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Abstract #1578

Three-Dimensional Models of Tissue Microstructure for Simulating High-Precision Diffusion MRI Data

Eleftheria Panagiotaki1, Matt G. Hall1, Bernard Siow1,2, Mark F. Lythgoe2, Daniel C. Alexander1

1Centre for Medical Image Computing, Dept. of Computer Science, University College London, London, United Kingdom; 2Centre for Advanced Biomedical Imaging, University College London, London, United Kingdom

This work outlines a method to construct detailed three-dimensional geometric models of tissue microstructure using confocal laser scanning microscopy (CLSM) images. We use these models to simulate the diffusion MRI signal from the tissue by running random-walk simulations within the resulting mesh. The precise simulated data from our method provide a mechanism for evaluating the quality of simple parametric models and the parameter estimates they provide.