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Abstract #1581

On the Influence of the Temporal Gradient Profile on the Apparent Diffusion Coefficient in the Motional Narrowing Regime in Closed Geometries

Frederik Bernd Laun1, Bram Stieltjes

1Medical Physics in Radiology, German Cancer Research Center, Heidelberg, Baden-Wrttemberg, Germany

In DWI, the apparent diffusion coefficient is determined by both, the diffusion process and the temporal profile of the diffusion gradients. In this work a technique to determine the influence of the temporal gradient profile on the measured ADC is developed for the motional narrowing regime in closed geometries. It yields a direct series expansion in powers on inverse time. It is shown that the discontinuities and integrals over the derivatives of the gradient profile determine the constants of this series expansion.