Li-Wei Kuo1, Wen-Yang Chiang2,
Fang-Cheng Yeh, 1,3, Van Jay Wedeen4, Wen-Yih Isaac
Tseng1,5
1Center for Optoelectronic Biomedicine,
National Taiwan University College of Medicine, Taipei, Taiwan; 2Center
for Bioengineering and Bioinformatics, The Methodist Hospital Research
Institute and Department of Radiology, The Methodist Hospital, Houston, TX,
United States; 3Department of Biomedical Engineering, Carnegie
Mellon University, Pittsburgh, PA, United States; 4MGH Martinos
Center for Biomedical Imaging, Harvard Medical School, Charlestown, MA,
United States; 5Department of Medical Imaging, National Taiwan
University Hospital, Taipei, Taiwan
The
present study investigated the optimum parameters for body-centered-cubic
sampling scheme as well as its accuracy of mapping complex fiber orientations
compared with grid sampling scheme of diffusion spectrum imaging. A
systematic angular analysis was performed on in-vivo data simulation and
verification studies. Ours results showed that body-centered-cubic sampling
scheme provided an incremental advantage in angular precision over the grid
sampling scheme. Further, the capacity of half-sampling schemes based on the
concept of q-space symmetry was also demonstrated. By considering the
efficiency, this study showed that body-centered-cubic and half-sampling
schemes may be potentially helpful for future clinical applications.
Keywords