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Abstract #1608

Effects of Diffusion Time on Diffusion Tensor Derived Parameters Measured on the Rat Brain at Ultrahigh Magnetic Field

Yohan van de Looij1,2, Nicolas Kunz1,2, Petra S. Hppi1, Rolf Gruetter2,3, Stphane V. Sizonenko1

1Division of Child Growth & Development, Department of Pediatrics, University of Geneva, Geneva, Switzerland; 2Laboratory for Functional and Metabolic Imaging, Ecole Polytechnique Fdrale de Lausanne, Lausanne, Switzerland; 3Department of Radiology, University of Geneva and Lausanne, Geneva and Lausanne, Switzerland

A large number of small bore systems propose implemented sequences making easy the use of DTI but the choice of sequence parameters can have a huge impact on the derived tensor quantifications. The aim of this work was to study the influence of diffusion time (td) and brain microstructures on diffusion derived parameters in the rat brain at 9.4T. 3 repeated DTEPI images (4 shots) were performed with td = 10, 25 and 39 ms respectively. This study shows in white and gray matter a dependence of diffusion derived parameters on td from 10 ms to 25 ms.